Extended Data Fig. 1: Hepatic senescence markers are associated with insulin resistance.
From: BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH
(a) Adipo-IR index in lean, NAFLD, and NASH individuals. (b) Correlation comparisons of Adipo-IR with hepatic senescence markers. (c) RT-qPCR analysis of hepatic senescence markers including p16, p21, and SA-β-Gal, in T2D individuals compared to non-diabetic individuals within lean, NAFLD, and NASH individuals. (d, f, h) Measurement of FPI (d), FPG (f), and GIR (h) in lean, NAFLD, and NASH individuals. (e, g, i) Correlation comparisons of mRNA levels of hepatic senescence markers with FPI (e), FPG (g), and GIR (i). Data were collected in lean subjects (n = 12), NAFLD subjects (n = 22), and NASH subjects (n = 24). Associations were determined using Spearman correlation analysis. Values are mean ± SEM. Statistical significance was determined by one-way ANOVA with post-hoc Tukey’s test or Kruskal-Wallis with post-hoc Dunn’s test. FPI, Fasting plasma insulin; FPG, fasting plasma glucose; GIR, glucose infusion rate.
