Extended Data Fig. 2: The distinct roles of ORM1 and ORM2 in the improvement of liver steatosis.
From: Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis
Related to Fig. 4. a-h, 8-week-old ob/ob male mice were administered with equal amount of Ad-ORM1, Ad-ORM2, or Ad-GFP through tail vein injection. a, b, Relative mRNA levels (a, n = 8 biologically independent mice per condition) and protein expression (b, n = 4 biologically independent mice per condition) of ORM1 and ORM2 in the livers from three groups of mice. c-i, Body weight (c), average daily food intake for 3 consecutive days (d), liver/body weight ratio (e), hepatic TG levels (f), plasma TG (g) and TC (i) levels. (c-i) n = 8 biologically independent mice per condition. h, Macroscopic appearance of liver, H&E and Oil Red O staining of liver sections. Scale bar, 50 μm. Representative result from three biologically independent mice. Data are shown as mean ± SEM (a, c-g, i). P values are determined by one-way ANOVA followed by Dunnett’s multiple comparisons test (a, c-g, i).
