Extended Data Fig. 5: Characterization of the concordant/discordant MZ co-twin groups.
From: Independent phenotypic plasticity axes define distinct obesity sub-types
a, Boxplot showing the inter-quartile ranges (IQR) of co-twin discordance indices for all the available features in either MZ or dizygotic (DZ) co-twins. b, Boxplot showing the MZ co-twin discordance indices for the indicated morphometric features, in the concordant/discordant groups identified. A horizontal dashed line highlights zero values of the discordance index (that is, concordance). Vertical dashed lines separate fat/lean/total mass and percentage of fat from the indicated body parts. c, UMAP projection of MZ co-twin couples from TwinsUK (n = 153), according to 35 morphometric discordances. Each observation represents a twin pair, colored by the whole-body fat (above) or lean (below) mass discordance (calculated as the difference between log-transformed measurements). The different shapes of the co-twin pairs represent the identified groups, as indicated. Dotted red/green lines highlight the Type-A and Type-B UPV and show their differences with respect to lean mass discordance. d, Box-plots representing the average height, between the ‘light’ and ‘heavy’ MZ co-twins, belonging to the indicated groups. Solid horizontal lines represent medians. The p-value is calculated by ANOVA. e, Boxplot showing the MZ co-twin discordance indexes for the indicated morphometric features, after height-normalization, in the concordant/discordant groups identified. A horizontal dashed line highlights the zero value of the discordance index (that is, concordance). Box plots in (b,d,e) show the lower and upper hinges = 25th and 75th percentiles. The upper/lower whiskers = largest/smallest observation less/greater than upper/lower hinge + 1.5 * IQR. Central median = 50% quantile.
