Extended Data Fig. 6: Inhibition of ABAT suppresses T cell proliferation and differentiation in vivo.
From: GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation
a–c, As illustrated by the experimental diagram of competitive antigen (OVA)-specific proliferation (a, top), the donor cell ratio (a, bottom and b), CFSE dilution (a, bottom), and indicated protein levels (a, bottom and c), were determined by flow cytometry (n = 3 biologically independent samples). b, c, Data are shown as mean ± SEM, significance was calculated by unpaired Two-tail Student’s t-test. ns, no significant differences. d–e, As illustrated by the experimental diagram of competitive homeostatic proliferation (d, top). The donor cell ratio (d, bottom, and e) and CFSE dilution (d, bottom) were determined by flow cytometry (n = 3 biologically independent samples). e, Significance was calculated by unpaired Two-tail Student’s t-test. CSA: cervical, submandibular and axilla.
