Extended Data Fig. 5: Hierarchical cluster trees of HypoMap split into neuronal (A) and non-neuronal (B) populations.
From: HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus
Similar to Fig. 2A, but split into neuronal (a) and non-neuronal (b) populations. The first 5 levels with up to 185 clusters are shown. Individual clusters at levels 4 and 5 are named with the most informative marker gene, given as edge labels. The inner (red) circular heatmap depicts the contribution of each dataset to the clusters at the lowest tree level in percent. The middle heatmap (blue) depicts the relative contribution of each cluster at the lowest tree level to the total cell number in percent. The scale is limited to 2%. The outer ring depicts the most likely region of origin (R) for each neuron cluster on the lowest level of the displayed tree. If support was insufficient for a cluster, no region was assigned and the cluster was colored in grey (see methods). For the non-neuronal cell types in (b) no regional prediction was conducted.
