Fig. 3: Comparison of HypoMap and original clusters.
From: HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus
a, HypoMap UMAP highlighting the cluster C25-3: GLU-3, which contains Nr5a1- and Fezf1-expressing neuronal populations from the VMH that are compared in b–e. b,c, UMAP plot of cells from the C25-3: GLU-3 cluster from Chen et al.34 (b) and Kim et al.32 (c) overlayed on all cells of the cluster (gray) and colored by the original author annotations. d,e, Sankey diagrams showing the original author annotations of Chen et al. (d) and Kim et al. (e), compared with the HypoMap subclusters (C286) of C25-3: GLU-3. Chen et al. (d) covered VMH neurons only sparsely, and the combination with other datasets greatly improves cell classification. The VMH-specific dataset from Kim et al. (e) covered most subclusters identified in HypoMap, although in some cases clusters were further partitioned. (See Supplementary Table 20 for a full overview of all original and HypoMap cell labels).
