Fig. 8: Graphical abstract. Schematic showing that Nrg4 plays a protective role in atherosclerosis via ErbB4–Akt–NF-κB signaling pathway. | Nature Metabolism

Fig. 8: Graphical abstract. Schematic showing that Nrg4 plays a protective role in atherosclerosis via ErbB4–Akt–NF-κB signaling pathway.

From: RETRACTED ARTICLE: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice

Fig. 8

This work describes that BAT-derived Nrg4 serves as a potential cross-talk factor between BAT and arteries and attenuates endothelial inflammation or adhesion responses, inhibits leukocyte homing and reduces endothelial injury or atherosclerosis in a manner involving Akt–NF-κB signaling. Thus, BAT-derived Nrg4 may become a new therapeutic drug for atherosclerosis and BAT could serve as a new target for atherosclerosis.

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