Extended Data Fig. 2: Identification of major EC subtypes across organs.
(a) Assignment of arterial + arteriole (art), capillary (cap) and veins + venule (ven) identities to ECs in each organs. The identities were defined based on markers presented in panel (b). Cells indicated in gray are specialized ECs that don’t broadly fit into the art, cap and ven EC categories. (b) UMAPs showing representative markers of art, cap and ven ECs for each organ. All markers, including the representatives shown here, were derived from published scRNA-seq datasets11,13,16,17,18. Arrows mark the respective positive cell populations. (c) Number of differentially expressed genes (DEGs) in the art, cap and ven ECs after down-sampling. Down-sampling to 73 ECs was done to ensure equal statistical power in each group. As down-sampling also resulted in lower statistical power, a lenient cut-off of p < 0.05 (rather than Benjamini-Hochberg adjusted p-value < 0.05) was used.
