Extended Data Fig. 1: HK expression in human and mouse microglia. | Nature Metabolism

Extended Data Fig. 1: HK expression in human and mouse microglia.

From: Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity

Extended Data Fig. 1

(a) A correlation network graph of genes in metabolic pathways (1147 genes) expressed in different types of brain cells (data retrieved from GSE52564). Nodes represent transcripts, while edges represent the degree of correlation in expression. Heatmaps and line charts showing the expression profile of transcripts contained within 3 clusters corresponding to astrocytes, endothelial cells and microglia clusters are presented. (b) Principal component analysis (PCA) of the metabolic genes in glycolysis/gluconeogenesis in 7 cell types of the brain (data retrieved from GSE52564). (c) A comparison of metabolic gene expression in human and mouse microglia (data retrieved from GSE89960). (d-f) The expression of Hk1, Hk2 and Hk3 in mouse brain cells (data retrieved from GSE52564), n = 2 mice per group. MG, Microglia; ECs, Endothelial cells; OPC, Oligodendrocyte progenitor cells; Neu, Neurons; MO, Myelinating oligodendrocytes; NFO, Newly formed oligodendrocytes; Ast, Astrocytes. Data are presented as means ± SEM.

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