Extended Data Fig. 4: Pathway overrepresentation of Kla sites in each quadrant.
a, Pathway enrichment of lactylproteins. Pathways with adjusted P value < 0.01 are shown. All pathways are composed of upregulated Kla in tumours compared with adjacent livers. There are no pathways for downregulated ones in the tumours compared with the adjacent livers that meet the need of adjusted P value < 0.01. b, Barplots showing the highly represented pathways with adjusted P value < 0.01. The quadrants marked on top correspond to Fig. 2c, representing the number of Kla sites on differentially expressed Oncogene/TSG between tumours and adjacent livers. c, Overlap among mRNA, protein, lactylprotein for the Cancer Gene Census (CGC). The schematic diagram of the quadrants in lactylprotein corresponds to the quadrants in Fig. 2a. P value is calculated by hypergeometric test and adjusted by Benjamini–Hochberg method (a,b).
