Extended Data Fig. 5: Subanterior rectus sheath transplantation of hPSC islets improved glycemic control in immunosuppressed diabetic rhesus macaques.
a-d, Daily fasting blood glucose levels of diabetic macaque recipients before STZ treatment (gray), before (brown) and after (black) subanterior rectus sheath transplantation of hPSC islets (infusion procedure conducted at day 0). e-h, Blood glucose levels of diabetic monkeys at 1 month before transplantation (Pre-Tx) and 3 months after sub-rectus sheath transplantation (9 - 12 wpt) (n = 28 independent values). i, C-peptide secretion levels of four diabetic monkeys (Monkey 5 - 8) before transplantation (Pre-Tx), 6 weeks (6 wpt) and 3 months (3 mpt) after sub-rectus sheath transplantation (n = 4 monkeys). The C-peptide secretion level of diabetic monkeys at 3 months after intraportal infusion of hPSC islets (Du et al., 3 mpt) was cited for comparison (n = 4 monkeys). Data presented as mean ± SEM. Two-tailed t-test was used to determine significance between groups and P value was indicated above the bars.
