Extended Data Fig. 5: Gut microbiome from CR treatment exerted anti-tumor effect depended on CD8.
From: The antitumour effects of caloric restriction are mediated by the gut microbiome
(a) MC38 tumor growth kinetics. The experimental design: Mice were transplanted the gut microbiome from CR treated mice, followed by anti-CD8 antibody treatment. FMT: Fecal microbiota transplantion. n = 5 mice. Data are mean ± s.e.m. Statistical analysis was performed using two-way ANOVA. (b,c) Representative images of dissected tumors (b) and tumor weights (c) on the 26th day. n = 5 mice. (d) Representative flow cytometry plots for one mouse/group were shown. (e) The percentage of tumor-infiltrating IFNγ+CD8+T cells in the tumor tissues. Data were mean ± s.e.m. (c,e) Statistical analysis was performed using unpaired two-tailed t-test.
