Fig. 1: Summary-based comparison of concordant and discordant profiles.
From: A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes
Concordant and discordant GRS coefficients for traits where we found differences between profiles using GWAS summary data. All are per-allele effect sizes, in s.d. units for continuous outcomes and ORs for binary traits (diseases and self-reported medication). Traits shown had at least one estimate significant after 5% FDR correction and the difference between profiles was also significant after 5% FDR. Statistical tests were based on a z-distribution and were two-sided. Bars show 95% CIs. Sample sizes vary for every trait (N > 100,000 for all traits).
