Fig. 2: Comparison of concordant and discordant profiles in BioVU.
From: A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes
Concordant and discordant GRS coefficients for traits where we found differences between profiles in BioVU. Analyses of disease endpoints included data for up to 48,544 individuals. Continuous outcomes included data for up to 68,724 and 13,661 individuals of European and African descent, respectively. All are per-allele effect sizes, in s.d. units for continuous outcomes and ORs for disease endpoints. Traits shown had at least one estimate significant after 5% FDR correction and the difference between profiles was also significant after 5% FDR. Statistical tests were based on a z-distribution and were two-sided. Bars show 95% CIs. CRP, C-reactive protein.
