Fig. 3: Comparison of concordant and discordant profiles in molecular phenotypes.
From: A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes
Concordant and discordant GRS coefficients for traits where we found differences between profiles in molecular phenotypes. All are per-allele effect sizes, in s.d. units. Findings in metabolites shown here are derived from TwinsUK + KORA F4 (N = 7,824) and the UK Biobank (N = 115,078). Protein data were derived from the INTERVAL study (N = 3,301). Traits shown in these two domains had at least one estimate significant after 5% FDR correction, and the difference between profiles was also significant after 5% FDR. Statistical tests were based on a z-distribution and were two-sided. Bars show 95% CIs. Microbiome data came from the MiBioGen consortium (N = 18,340); the genii shown here had at least one estimate nominally significant, and the difference between estimates was also nominally significant (two-sided P < 0.05).
