Fig. 4: Genes with likely discordant pleiotropic effects on BMI and T2D.
From: A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes
Genes with likely pleiotropic, yet discordant, effects on BMI and T2D, as found in the SMR & HEIDI analysis. Genes were sorted by their chromosome location and tissue where the pleiotropic association was found, as well as the lead expression quantitative trait loci (eQTL). The first three panels comprise the effect sizes of the lead eQTL on BMI (s.d. units), gene expression/splicing (normalized effect size) and T2D risk (OR), respectively. Bars represent 95% CIs. The right panel represents the logarithm of the tissue-of-action score. BMI data were derived from the GIANT + UK Biobank meta-analysis (N = 681,275). Gene expression data came from the GTEx (N = 838) and eQTLGen consortia (N = 31,684). T2D data came from the DIAGRAM meta-analysis dataset (N = 158,186).
