Extended Data Fig. 1: Analysis flowchart and profile identification.
From: A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes
Panel A: Analysis flowchart. Panel B: BMI and T2D risk estimates of concordant and discordant SNPs after alignment to the BMI increasing allele. Panel C: summary-based concordant and discordant GRS coefficients (standard deviation units for continuous traits, log OR for binary traits). Traits shown have at least 1 estimate significant after 5% FDR correction and the difference between profiles is also significant after 5% FDR. Statistical tests were based on a Z-distribution and were two-sided. Bars show 95% confidence intervals. Sample sizes vary for every trait (> 100.000 for all traits). The heatmap shows the Z-scores of the SNPs in every trait, with the single-linkage tree at the bottom, separately for concordant and discordant SNPs.
