Extended Data Fig. 2: Traits with potential causal effect on diabesity discordance.
From: A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes
Panel A: Traits where a difference was found in the comparison of profiles and one of the two direction-specific GRS associated with BMI was associated with lower risk of T2D (two-sided Z-statistic P < 0.05). To derive the GRS we used BMI data from the GIANT + UK Biobank meta-analysis (N = 681,275). WHR data came from the GIANT consortium (N = 212,244). SBP data came from the meta-analysis performed by the ICBP (N = 757,601). Metabolite data came from the UK Biobank (N = 115,078). Estimates represent T2D OR, bars represent 95% confidence intervals, which are derived from the DIAGRAM meta-analysis (N = 158,186). Panel C: Regional association plot showing the pleiotropic effect of genetic instruments for blood levels of TIMP4 protein and high BMI and lower T2D risk. Protein data was derived from the INTERVAL study (N = 3,301).
