Fig. 5: Glucose and insulin intolerance in Irg1−/− and Irg1fl/fl × LysMCre mice after WD feeding.
a, Blood glucose levels following a single dose challenge of 2 g kg−1 glucose of the indicated mice. The graph depicts n = 5 mice from one experiment, representative of three total experiments. b, Area under the curve for the glucose tolerance test (*P = 0.04; n = 5). c, Blood glucose levels following a single dose challenge of 0.5 U kg−1 insulin of the indicated mice (n = 5 mice per group). d, Area under the curve for the insulin tolerance test (*P = 0.031; n = 5). e, Serum insulin levels at 12 weeks (*P = 0.03; **P = 0.001; n = 5 mice per group). f, Mouse weight measurements, as percentage of day 0 starting weight, during the 12 weeks of control or WD feeding. g,h, Insulin intolerance in Irg1fl/fl × LysMCre mice was determined by feeding mice control (g) or WD (h) for 12 weeks and blood glucose levels were monitored over time following a single-dose challenge of insulin of the indicated mice. The graphs depict n = 5 mice per experiment, representative of three similar experiments. Data are presented as mean ± s.e.m. A two-sided ANOVA with multiple comparisons was used for statistical analyses.
