Extended Data Fig. 2: CaMK1D signaling is redundant in pancreatic beta cell and liver function.
From: CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake
a, Blood insulin levels during IPGTTs in mice on a High fat diet (HFD). (n = 11/group). b, Glucose-stimulated insulin secretion (GSIS) in pancreatic islets isolated from mice. (CaMK1D+/+ n = 6; CaMK1D−/− n = 5). c, Expression of CaMK1D protein in pancreas and brain from mice with indicated genotypes. d, Body weight gain of mice on a Chow diet (CD) or on a High Fat Diet (HFD). (CD - CaMK1Dflox/flox n = 13; CD - AgRPCre/+; CaMK1Dflox/flox n = 13; HFD - CaMK1Dflox/flox n = 12; CD - AgRPCre/+; CaMK1Dflox/flox n = 10). e-f, Blood glucose levels during IPGTTs in mice on a CD (e), or on a HFD (f). (CD - CaMK1Dflox/flox n = 7; CD - AgRPCre/+; CaMK1Dflox/flox n = 6; HFD - CaMK1Dflox/flox n = 7; CD - AgRPCre/+; CaMK1Dflox/flox n = 8). g, Expression of CaMK1D mRNA in liver from mice. (CaMK1Dflox/flox n = 3; CD - AlbCre/+; CaMK1Dflox/flox n = 3) h, Body weight gain of mice on a CD or on a HFD. (CD - CaMK1Dflox/flox n = 8; CD - AlbCre/+; CaMK1Dflox/flox n = 9; HFD - CaMK1Dflox/flox n = 8; HFD - AlbCre/+; CaMK1Dflox/flox n = 10). Blood glucose levels during an IPGTT in mice on a CD (i) or on a HFD (j). (CD - CaMK1Dflox/flox n = 6; CD - AlbCre/+; CaMK1Dflox/flox n = 7; HFD - CaMK1Dflox/flox n = 8; HFD - AlbCre/+; CaMK1Dflox/flox n = 5). Blood glucose levels during an ITT in mice on a CD (k) or on a HFD (l). (CD - CaMK1Dflox/flox n = 5; CD - AlbCre/+; CaMK1Dflox/flox n = 6; HFD - CaMK1Dflox/flox n = 12; HFD - AlbCre/+; CaMK1Dflox/flox n = 14). Data are presented as mean values +/− SEM.
