Table 2 Differential effects of liraglutide on neural tracking of the adaptive prediction error

From: Liraglutide restores impaired associative learning in individuals with obesity

 

Cluster level

Peak level

 

PFWE-corr

Size

t

x

y

z

Interaction

dACC

0.004

704

4.69

18

38

16

lOFC

  

4.21

26

48

−12

SCA

  

3.97

14

24

−14

vmPFC

  

3.95

16

42

−10

vStr/NAc

  

3.71

16

16

−8

IS+: liraglutide > placebo

No significant clusters

IS–: liraglutide > placebo

vmPFC

0.001

342

4.67

16

42

−14

lOFC

  

3.79

30

46

−12

dACC

0.033

12

4.05

18

38

16

SCA

0.013

71

3.97

14

28

−16

vStr/NAc

  

3.72

16

16

−8

  1. Statistics for t-contrasts identifying brain regions in which liraglutide (relative to placebo) enhanced the encoding of learning to a greater extent in the group with impaired insulin sensitivity (IS–) than in the group with normal insulin sensitivity (IS+). In addition to this interaction effect, we tested for the liraglutide effect within the IS+ and IS– groups, respectively, masked with the corresponding interaction result. The statistical threshold was P < 0.05, and data were family-wise error corrected at the cluster level (PFWE-corr), with an underlying voxel-level threshold of P < 0.001. Corresponding brain activation maps are shown in Fig. 3.
  2. dACC, dorsal anterior cingulate cortex; lOFC, lateral orbitofrontal cortex.
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