Extended Data Fig. 7: Reference mapping and cell state transfer for external mouse dataset β-cells reveals expected reference and query sample relationships.
From: Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas
(a) Joint embedding of the atlas (reference) and the external mouse dataset (query). Left: All query samples, named as age, treatment and replicate when multiple samples with the same age and treatment were present. Right: Reference cell groups showing coarse β-cell states, as shown in Fig. 5a, and proliferative (part of the ‘endocrine proliferative’ atlas cluster) and embryonic β-cells (as annotated in the original study of the embryonic dataset). (b) Label transfer from the atlas to query, using cell groups as described in a. Cells with low label-transfer probability were assigned to the uncertain group. Shown are the ratios of each query sample predicted as a certain cell group.
