Extended Data Fig. 8: Regulation of Glut2 expression in CD8+ T cells.
From: The glucose transporter 2 regulates CD8+ T cell function via environment sensing
(a) Upon T cell activation expression of Glut 2 is upregulated on the T cell surface, where it localizes in lipid rafts via association with Stomatin. Stomatin competes with Galectin-9 (Gal-9) which segregates Glut2 in the non-raft membrane, where it is internalized. (b) Once T cells reach the circulation, they are exposed to increased glucose concentration, oxygen tension, and physiological pH which, by inhibiting HIF1α activation and subsequent Gal-9 transcription, further promote Glut2 expression, glucose uptake and storage as Glycogen. (c) Once in the inflammatory site, a drop in oxygen tension and pH upregulate Gal-9 expression, removal of Glut2 from lipid raft domains and subsequent internalization. This prevents passive loss of intracellular glucose in conditions of low extracellular availability.
