Extended Data Fig. 8: TAZ deficiency induces changes in Drosophila melanogaster lipidome.
From: Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome
Typical mass spectra of MLCL (a) and CL (b) obtained from control (W1118) and (TAZ889) mutant flies. Content MLCL containing C18:2 (c) and C18:3 (d) in control W1118 and TAZ889 deficient flies. Lipidomics analysis was performed using 6 vials (n = 20 fly torsos per vial). (c) *P = 0.0401, **P < 0.0015, ***P = 0.0005 unpaired two-tailed t-test. (d) *P = 0.0378, **P < 0.0019, ****p < 0.0001 unpaired two-tailed t-test. (e) TPP-IOA did not significantly affect the endurance of control flies. Endurance was measure using 8 vials (N = 20 flies) and significance was determined by log-rank analysis., ns = not significant. (f) Content of CL (left panel) and MLCL (right panel) in control W1118 flies after feeding with TPP-IOA. Lipidomics analysis was performed using 6 vials (n = 20 fly torsos per vial). For all violin plots presented, individual points including maximal and minimal are shown as black circles. Dashed black line indicates median and doted lines indicate quartiles.
