Extended Data Fig. 5: In vitro functional activity comparison between AMG 133 and hGIPR-Ab/P1. | Nature Metabolism

Extended Data Fig. 5: In vitro functional activity comparison between AMG 133 and hGIPR-Ab/P1.

From: A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings

Extended Data Fig. 5

(a) Representative dose-response curves of cAMP assays with GIP (agonist mode) and AMG 133 or hGIPR-Ab/P1 + 50 pM GIP (antagonist mode) in cells expressing human GIPR. Data are represented as mean ± SEM of n = 2 replicates per treatment. (b) Representative dose-response curves of cAMP assays with GLP-1, AMG 133 or hGIPR-Ab/P1 in cells expressing human GLP-1R. Data are represented as mean ± SEM of n = 2 replicates per treatment.

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