Extended Data Fig. 2: In vitro functional activity of AMG 133 or AMG 133 murine surrogate. | Nature Metabolism

Extended Data Fig. 2: In vitro functional activity of AMG 133 or AMG 133 murine surrogate.

From: A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings

Extended Data Fig. 2

(a–d) Representative dose-response curves of cAMP assays in cells expressing human GIPR (A), human GLP-1R (B), mouse GIPR (C), or mouse GLP-1R (D). 50 pM or 90 pM GIP was used in the antagonist mode (A&C) of the assay. Data are represented as mean ± SEM of n = 2 replicates per treatment.

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