Fig. 2: Identification of common SAMS.

a–d, Fold change of the ratios between the indicated metabolites in WI38 fibroblasts undergoing RAS OIS (n = 3), RAF OIS (n = 3), DDIS (n = 3) and RS (n = 6) measured for each treatment at the last time point of the kinetics and relative to the values of proliferating cells. The pEtN:CDP-Etn ratio in RS was calculated using D11 as a proliferative control. Bars represent the means of biological replicates ± s.d. Indicated P values were calculated using an unpaired two-sided Student’s t-test.