Fig. 3: Senescence repression correlates with SAMS repression. | Nature Metabolism

Fig. 3: Senescence repression correlates with SAMS repression.

From: A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Fig. 3

a, Percentage of SABG-positive cells of cultures of WI38 fibroblasts non-treated (Prolif.) undergoing DDIS in the presence or the absence of rapamycin for 7 days. b, Percentage of SABG-positive cells of WI38 fibroblasts non-treated (Prolif.) or undergoing RAS-induced senescence (RAS OIS) treated or not with DMOG for 7 days. c,d, GSEA enrichment of SASP genes of DDIS rapamycin-treated cells (14 days) (c) and RAS OIS DMOG-treated cells (7 days) (d). NES, normalized enrichment score. e,f, Fold changes of SAMS in WI38 fibroblasts undergoing DDIS ± rapamycin for 14 days (e) and RAS OIS ± DMOG for 7 days (f). For a,b,e,f, bars represent the means of three biological replicates ± s.d. Indicated P values were calculated using an unpaired two-sided Student’s t-test.

Source data

Back to article page