Extended Data Fig. 4: Lactate levels and body weight changes in mouse xenograft models.
From: Activation of GPR81 by lactate drives tumour-induced cachexia
a-c, Blood lactate level (a), body weight (b), and tissue weights of inguinal white adipose tissue (iWAT), gonad white adipose tissue (gWAT) and quadriceps (c) of tumour-free (Control) and B16-F10 (B16) xenograft mice (n = 5 for each group). d-f, Blood lactate level (d), body weight (e), and tissue weights (f) of Control and EMT6 xenograft mice (n = 5 for each group). g-i, Blood lactate level (g), body weight (h), and tissue weights (i) of Control and MIA PaCa-2 xenograft (MIA) mice (n = 5 for each group). j, Weights of xenograft tumours derived from different cancer cells (n = 5 for each group). All data are presented as the mean ± s.e.m. P values were determined by two-tailed unpaired Student’s t-test (a, c, d, f, g, i), two-way ANOVA (b, e, h), or one-way ANOVA with Tukey’s multiple comparisons test (j).
