Extended Data Fig. 9: Schematic illustration depicting the signaling cascade downstream of lactate/GPR81 in promoting cancer cachexia.
From: Activation of GPR81 by lactate drives tumour-induced cachexia
Activation of GPR81 by lactate instigates adipose tissue browning via Gαi/o-Gβγ-RhoA-ROCK1-p38 signaling cascade, which promotes the development of cachexia. Created with BioRender.com.
