Extended Data Fig. 3: Differential serum metabolites in the patients with versus without cancer cachexia.
From: Activation of GPR81 by lactate drives tumour-induced cachexia
a, PLS-DA of untargeted metabolomics profiling of serum samples from lung adenocarcinoma patients with or without cachexia (Cachexia and Non-cachexia, respectively; n = 3 for each group). b, Volcano plot showing the differential metabolites in the serum samples from patients with or without cancer cachexia. Metabolites with log2(fold change) ≥ 0.5 or ≤ 0.5 and P value < 0.05 were considered significantly different. Lactate, -log10(P value) = 1.49, log2(fold change) = 1.54. c, The serum lactate level in patients with or without cancer cachexia (Non-cachexia, n = 9; Cachexia, n = 17). d,e, The KEGG pathways enriched by analyzing the differential metabolites in the serum samples from cancer patients. All data are presented as the mean ± s.e.m. In panel c, P values were determined by two-tailed unpaired Student’s t-test.
