Extended Data Fig. 4: Temporal changes in the proteome and transcriptome during adipogenesis.
(a) Pearson correlation coefficients between protein and mRNA levels at each indicated time point of differentiation in hAPCs. The datasets were filtered for the temporally conserved core proteome from (1H). (b) Supervised hierarchical clustering of z-scored profiles at protein and mRNA levels. (c) Z-scored protein and mRNA profiles of indicated proteins. (d) Histogram of Pearson correlation values between the temporal protein and mRNA profiles of proteins, including all time points present in both datasets. (e) Z-scored protein and mRNA profiles of indicated proteins. (f) 1D annotation scores of representative GO-terms, keywords, and KEGG pathways enriched among pathways with high and low temporal mRNA and protein correlations (two-sided 1D annotation enrichment, Benjamini-Hochberg FDR < 0.1).
