Extended Data Fig. 3: GLP-1R agonist liraglutide improves B. vulgatus-induced PCOS-like phenotype.
a, The levels of GIP in patients with PCOS and healthy control serum. b, The levels of GDF15 in patients with PCOS and healthy control serum. c, The correlation between the total GLP-1 level in the serum and LH/FSH ratio. d, The correlation between the total GLP-1 level in the serum and HOMA-IR. e, Quantitative analysis of cystic follicles in the ovaries. f, Area under the curve (AUC) of GTT. g, The levels of fasting glucose in serum. h, The level of insulin in serum. All data are presented as the mean ± s.e.m. (a-d) n = 20 in the control group and n = 20 in the PCOS group. (e) n = 5/group. (f-h) n = 6/group. In a, the P values were determined by two-tailed Mann–Whitney U-test. In b, the P values were determined by two-tailed Student’s t-test. In c, d, correlation analysis was determined by one tailed Pearson r-test. In e, the P values were determined by Kruskal–Wallis test followed by Dunn’s post hoc test. In f-h, the P values were determined by one-way ANOVA with Tukey’s multiple comparison post hoc test.
