Extended Data Fig. 5: GLP-1 receptor inhibitor reversed the improvement of B. vulgatus-induced PCOS-like phenotype in intestinal Fxr knockout mice. | Nature Metabolism

Extended Data Fig. 5: GLP-1 receptor inhibitor reversed the improvement of B. vulgatus-induced PCOS-like phenotype in intestinal Fxr knockout mice.

From: The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice

Extended Data Fig. 5

a, Quantitative analysis of corpora lutea in the ovaries. b, Quantitative analysis of cystic follicles in the ovaries. c, Area under the curve (AUC) of GTT. d, The levels of fasting glucose in serum. e, The level of insulin in serum. f, HOMA-IR. All data are presented as the mean ± s.e.m. (a-f) n = 5/group. In a, b, d, the P values were determined by Kruskal–Wallis test followed by Dunn’s post hoc test. In c, e, f, the P values were determined by one-way ANOVA with LSD test.

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