Extended Data Fig. 9: Representative images of MASLD histopathology features in the MC4R-WD-C0.2-21W model.

a. Panlobular distribution of steatosis, grade 3, H&E stain, x50; b. Necroinflammatory foci (arrowheads), H&E stain, x200; c. Ballooned hepatocytes (arrows), H&E stain, x200; d. Periportal and perisinusoidal fibrosis, stage 2, Sirius red fast green stain, x50 (THV terminal hepatic venule, PT portal tract).