Extended Data Fig. 10: Representative images of MASLD histopathology features in the LDLR-CDHFHCD-F42-C1-8W model.

a. Panlobular distribution of steatosis, grade 3, H&E stain, x50; b. Periportal and perisinusoidal fibrosis, stage 2, Sirius red stain, x50; c) Necroinflammatory foci (arrowheads), H&E stain, x200; d. Ballooned hepatocyte (arrow), H&E stain, x200 THV terminal hepatic venule, PT portal tract).