Extended Data Fig. 8: Stimulating Oxidative Phosphorylation Pharmacologically during the Early Active Phase Enhances Bone Growth.
From: Time of exercise differentially impacts bone growth in mice
a, ATP production of femur in Sed and Exe mice intraperitoneally injected oxidative phosphorylation activator or equal solvent (n = 3 biologically independent experiments). b, The content of NAD+ and NADH, and the ratio of NAD + / NADH of femur in Sed and Exe mice intraperitoneally injected oxidative phosphorylation activator or equal solvent (n = 3 biologically independent experiments). c, d, Western blot analysis of the levels of AMPKα1/α2, p-AMPKα1/α2, ATP6V0D1, COX IV, Cyclin D2, COL2α1 and ACAN in the femoral metaphysis tissue from Sed and Exe mice intraperitoneally injected oxidative phosphorylation activator or equal solvent (n = 6 biologically independent experiments). a, b, d, Data were presented as mean ± SD and analyzed using two-way ANOVA with Tukey multiple comparisons test.
