Extended Data Fig. 1: Exercise during the Early Active Phase Can Robustly Expedite Bone Growth.
From: Time of exercise differentially impacts bone growth in mice
a, b, Food intake (a) and body weight (b) of sedentary (Sed) and exercise (Exe) mice (n = 12, Sed, Exe at ZT1, ZT5, and ZT 13 mice; n = 8, Exe at ZT9 mice; n = 11, Exe at ZT17 mice; n = 10, Exe at ZT21 mice; Data were presented as mean ± SD and analyzed using one-way ANOVA with Tukey multiple comparisons test). c, Images of calcein double labeling of the femoral diaphyseal cortical bones of Sed and Exe mice. Scale bar, 100 μm. d, e, Quantification of mineralization apposition rate (MAR) and bone formation rate (BFR) of the femoral metaphyseal cortical bones (n = 3 biologically independent experiments, Data were presented as mean ± SD and analyzed using one-way ANOVA with Tukey multiple comparisons test).
