Table 4 Significant univariable correlates of changes in indices of insulin sensitivity/insulin resistance with weight gain

From: Weight gain leads to greater adverse metabolic responses in South Asian compared with white European men: the GlasVEGAS study

 

Univariable correlate

r

95% CI

P

Change in fasting insulin concentration

Ethnicity

0.385

(0.059, 0.637)

0.02

Baseline visceral fat

0.482

(0.167, 0.708)

0.004

Baseline upper-body adipose tissue

0.424

(0.094, 0.670)

0.01

Baseline proportion of small adipocytes

−0.454

(−0.700, −0.112)

0.01

Baseline volume of small adipocytes

−0.421

(−0.678, −0.071)

0.02

Baseline proportion of medium adipocytes

0.411

(0.059, 0.672)

0.01

Baseline volume of medium adipocytes

0.430

(0.082, 0.684)

0.02

Change in proportion of very small adipocytes

0.427

(0.079, 0.682)

0.02

Change in volume of very small adipocytes

0.488

(0.155, 0.721)

0.006

Change in postprandial insulin concentration

Ethnicity

0.413

(0.092, 0.656)

0.01

Baseline ASAT

0.403

(0.070, 0.656)

0.02

Baseline whole-body lean tissue

−0.370

(−0.633, −0.030)

0.03

Baseline mean adipocyte diameter

0.573

(0.268, 0.774)

0.001

Baseline adipocyte volume

0.621

(0.336, 0.802)

<0.0001

Baseline proportion of small adipocytes

−0.560

(−0.766, −0.250)

0.001

Baseline volume of small adipocytes

−0.663

(−0.866, −0.398)

<0.0001

Baseline proportion of large adipocytes

0.701

(0.456, 0.847)

<0.0001

Baseline volume of large adipocytes

0.644

(0.369, 0.815)

<0.0001

Change in HOMAIR

Ethnicity

0.410

(0.089, 0.654)

0.01

Baseline visceral fat

0.382

(0.044, 0.641)

0.03

Baseline upper-body adipose tissue

0.352

(0.010, 0.620)

0.05

Baseline proportion of small adipocytes

−0.441

(−0.691, −0.096)

0.02

Baseline volume of small adipocytes

−0.416

(−0.675, −0.066)

0.02

Baseline proportion of medium adipocytes

0.389

(0.033, 0.657)

0.03

Baseline volume of medium adipocytes

0.411

(0.060, 0.672)

0.02

Change in volume of very small adipocytes

0.412

(0.060, 0.672)

0.02

Change in Matsuda insulin sensitivity index

Ethnicity

−0.393

(−0.642, −0.068)

0.02

Change in visceral fat

0.348

(0.006, 0.618)

0.05

Baseline visceral fat

0.368

(0.028, 0.631)

0.04

Baseline ASAT

0.405

(0.071, 0.657)

0.02

Baseline whole-body lean tissue

−0.378

(−0.639, −0.040)

0.03

Baseline whole-body adipose tissue

0.395

(0.060, 0.650)

0.02

Baseline upper-body adipose tissue

0.413

(0.082, 0.663)

0.02

Baseline mean adipocyte diameter

0.603

(0.310, 0.971)

<0.0001

Baseline adipocyte volume

0.621

(0.335, 0.802)

<0.0001

Baseline proportion of small adipocytes

−0.592

(−0.785, −0.294)

0.001

Baseline volume of small adipocytes

−0.676

(−0.833, −0.418)

<0.0001

Baseline proportion of large adipocytes

0.683

(0.428, 0.837)

<0.0001

Baseline volume of large adipocytes

0.620

(0.335, 0.801)

<0.0001

Change in ISSI-2

Ethnicity

−0.410

(−0.654, −0.089)

0.01

Change in visceral fat

0.391

(0.055, 0.647)

0.03

  1. r and P values obtained from two-sided, univariable linear regression, without adjustment for multiple comparisons. CI, confidence interval.
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