Extended Data Fig. 3: Metabolic characterization of primary pancreatic cancer and liver metastatic cells in culture.
From: Cancer tissue of origin constrains the growth and metabolism of metastases
(a) Heatmap representation of unsupervised clustering of relative metabolite levels measured by LC-MS from paired primary and liver metastatic cells cultured in standard DMEM conditions; data is shown in triplicate per cell line from three independently derived cell lines. (b-j) Fractional labeling of each indicated metabolite in cells derived from a primary pancreatic tumor or a liver metastasis after being cultured with U-13C glucose for 24 hours. mean +/− stdev; data is shown from three independently derived cell lines; n=3.
