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A brief guide to studying extracellular vesicle function in the context of metabolism

Nature Metabolism volume 6, pages 1839–1841 (2024)Cite this article

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Extracellular vesicles (EVs) are now recognized as powerful modulators of metabolism, and thus the new field of EV-mediated metabolic regulation is growing exponentially. Here, we discuss special experimental considerations for the study of EV function in metabolism.

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Fig. 1: Experimental guidelines for studying and reporting the metabolic effects of EVs.

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Acknowledgements

C.C. is supported by the US National Institutes of Health (NIH; R00-DK122019), the American Heart Association (23IPA1054013) and the Diabetes Research Center (DRC) at Washington University, NIH P30DK020579. W.Y. is supported by the NIH (R21HD107516, R00DK115998, and R01DK125560).

Author information

Authors and Affiliations

  1. Department of Health and Exercise Science, College of Health and Human Sciences, Colorado State University, Fort Collins, CO, USA

    Daniel Stephen Lark

  2. Columbine Health Systems Center for Healthy Aging, Colorado State University, Fort Collins, CO, USA

    Daniel Stephen Lark

  3. Molecular Cell Biology, Institute for Theoretical Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany

    Kerstin Stemmer

  4. Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA

    Wei Ying

  5. Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA

    Clair Crewe

  6. Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA

    Clair Crewe

Authors
  1. Daniel Stephen Lark
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  2. Kerstin Stemmer
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  3. Wei Ying
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  4. Clair Crewe
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Contributions

D.S.L, K.S., W.Y. and C.C. wrote, revised, edited, and approved the manuscript. D.S.L generated the figure.

Corresponding author

Correspondence to Clair Crewe.

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Competing interests

K.S. has received funding and speaker honoraria from Novo Nordisk.

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Nature Metabolism thanks the anonymous reviewers for their contribution to the peer review of this work.

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Lark, D.S., Stemmer, K., Ying, W. et al. A brief guide to studying extracellular vesicle function in the context of metabolism. Nat Metab 6, 1839–1841 (2024). https://doi.org/10.1038/s42255-024-01112-w

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