Extended Data Fig. 2: Engraftment of CD45.1+ cells in blood, spleen, and liver in mice transplanted with wildtype or mtD2 bone marrow.
From: Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome
(a) Representative gating for identification of CD45.1+ CD45.2− donor immune cells and CD45.1− CD45.2+ radioresistant host cells. (b) Chimerism expressed as a percentage of the ratio of CD45.1+ cells to the sum of CD45.1+ and CD45.2+ cells. (c) Representative gating in the blood to exclude red blood cells (RBCs) and platelets from particles less than 2 µm in diameter for identification of extracellular mtD2+ mitochondria. Data are expressed as mean +/− SEM. All data points are unique biological replicates. For b, n = 3 WT, n = 5 mtD2 (except n = 4 for spleen). Data accompanies Fig. 2.
