Extended Data Fig. 6: Acarbose reshaped immune responses mainly through influencing chemokine profile within tumours. | Nature Metabolism

Extended Data Fig. 6: Acarbose reshaped immune responses mainly through influencing chemokine profile within tumours.

From: Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota

Extended Data Fig. 6

a, Significant enrichment in gene ontology (GO) functional terms (Top 20). Statistical significance was assessed using a two-sided hypergeometric test, with P values adjusted for multiple comparisons using the Benjamini-Hochberg method. b-c, Gene Set Enrichment Analysis (GSEA) plot and gene sets for T CELL ACTIVATION (b) and POSITIVE REGULATION OF CHEMOKINE PRODUCTION (c). d, Based on gut microbiota and crucial metabolites, network of associations was established based on the correlation between gut microbes and 122 immunomodulators (chemokines, receptors, MHC molecules, and immunostimulators). Correlation coefficients larger than 0.70 with adjusted P value < 0.05 were considered significant links. Statistical significance was determined by Fisher’s exact test.

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