Extended Data Fig. 3: SDH-deficiency is involved in the itaconate-interferon phenotype. | Nature Metabolism

Extended Data Fig. 3: SDH-deficiency is involved in the itaconate-interferon phenotype.

From: Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase

Extended Data Fig. 3

a, Sdhb and b, Il1b expression in Sdhbfl/fl and Sdhb−/− BMDMs (n=2 mice; LPS 4 h) from 2 independent experiments. c, IFNB expression in IRG1+/+ and IRG1−/− THP-1 cell lines pretreated with DMSO or TTFA (n=4 replicates; LPS/IFN𝛄 4 h) from 2 independent experiments d, IFNB expression in THP-1 derived macrophages pretreated with PBS or Mesaconate (n=4 replicates; LPS/IFNγ 4 h) from 2 independent experiments. Data are presented as mean ± SEM. P values were calculated using two-way ANOVA for multiple comparisons or two-tailed student’s t-test for pairwise comparisons.

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