Farnesyl pyrophosphate (FPP), an intermediate of cholesterol biosynthesis in the mevalonate pathway, prolongs the survival of migratory dendritic cells (mig-DCs) by remodelling mitochondrial structure and metabolism. Treating a mouse model of systemic lupus erythematosus with simvastatin (an inhibitor of this pathway) led to recovery from dysregulation in mig-DCs and ameliorated systemic autoimmune pathogenesis.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kelly, B. & O'Neill, L. A. Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res. 25, 771–784 (2015). This review presents the alterations and roles of immunometabolism of DCs in innate immunity and inflammation.
Liu, J., Zhang, X., Cheng, Y. & Cao, X. Dendritic cell migration in inflammation and immunity. Cell. Mol. Immunol. 18, 2461–2471 (2021). This paper reports the migratory routes and immunological consequences of distinct DC subsets and the relevance for autoimmune and infectious disease pathogenesis.
You, Z. & Chi, H. Lipid metabolism in dendritic cell biology. Immunol. Rev. 317, 137–151 (2023). This review describes the roles of fatty acid and cholesterol metabolism in orchestrating DC immunity in health and disease.
Plebanek, M. P. et al. A lactate–SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression. Sci. Immunol. 9, eadi4191 (2024). This paper shows that tumour lactate-stimulated SREBP2 signalling promotes CD63+ mregDC function and migration to tumour dLNs and thus suppresses anti-tumour immunity.
Liu, J., Zhang, X. & Cao, X. Dendritic cells in systemic lupus erythematosus: from pathogenesis to therapeutic applications. J. Autoimmun. 132, 102856 (2022). This review outlines the activation and function of the major DC subsets in the pathogenesis of SLE, as well as therapeutic applications.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Zhang, X. et al. Farnesyl pyrophosphate potentiates dendritic cell migration in autoimmunity through mitochondrial remodelling. Nat. Metab. https://doi.org/10.1038/s42255-024-01149-x (2024).
Rights and permissions
About this article
Cite this article
Farnesyl pyrophosphate modulates dendritic cell migration in lupus autoimmunity. Nat Metab 6, 2033–2034 (2024). https://doi.org/10.1038/s42255-024-01148-y
Published:
Issue date:
DOI: https://doi.org/10.1038/s42255-024-01148-y
