Fig. 1: Homozygous TBC1D4 p.Arg684Ter variant carriers display prolonged hyperglycaemia followed by hypoglycaemia during an extended oral glucose challenge. | Nature Metabolism

Fig. 1: Homozygous TBC1D4 p.Arg684Ter variant carriers display prolonged hyperglycaemia followed by hypoglycaemia during an extended oral glucose challenge.

From: Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise

Fig. 1

a, Graphical representation of the OGTT. b–i, Blood glucose (b) as well as plasma C-peptide (c), insulin (d), glucagon (e), adrenaline (f), noradrenaline (g), cortisol (h) and growth hormone (i) during an extended (6 h) OGTT. *Difference between TBC1D4 carriers and Controls at the given time point. ‡Different from basal (time 0) within the same group. One symbol P < 0.05. Two symbols P < 0.01. Three symbols P < 0.001. Symbols within parentheses represent P values between 0.1 and 0.05. n = 8 in Controls and n = 7 in TBC1D4 carriers. Data are means ± s.e.m. Data were analysed using a two-way repeated ANOVA test (one factor repeated) and two-tailed Student–Newman–Keuls post hoc analyses for multiple comparisons. Graphics in a created using BioRender.com.

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