Extended Data Fig. 1: Gut hormones during an extended oral glucose challenge in homozygous TBC1D4 p.Arg684Ter variant carriers. | Nature Metabolism

Extended Data Fig. 1: Gut hormones during an extended oral glucose challenge in homozygous TBC1D4 p.Arg684Ter variant carriers.

From: Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise

Extended Data Fig. 1

a, b, Plasma levels of GIP (a) and GLP-1 (b) during an extended (6-h) oral glucose tolerance test (OGTT). ‡Different from basal (time = 0) in both groups. Three symbols = P < 0.001. n = 8 in Controls and n = 7 in TBC1D4 carriers. Data are means ± SEM. Data were analyzed using a two-way repeated ANOVA test (one factor repeated) and two-tailed Student–Newman-Keuls post hoc analyses for multiple comparisons.

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