Extended Data Fig. 5: Leg glucose uptake, blood flow and arterial-venous glucose difference during euglycemic-hyperinsulinemic clamp conditions as well as whole-body substrate utilization and mitochondrial respiration in permeabilized muscle fibers from homozygous TBC1D4 p.Arg684Ter variant carriers. | Nature Metabolism

Extended Data Fig. 5: Leg glucose uptake, blood flow and arterial-venous glucose difference during euglycemic-hyperinsulinemic clamp conditions as well as whole-body substrate utilization and mitochondrial respiration in permeabilized muscle fibers from homozygous TBC1D4 p.Arg684Ter variant carriers.

From: Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise

Extended Data Fig. 5

a, b, Respiratory Exchange Ratio (RER) during an extended (6-h) oral glucose tolerance test (OGTT) (a) as well as before and at the end of the insulin clamp (b). c, Mitochondrial respiration rate (O2 flux) in permeabilized muscle fibers in the presence or absence of acylcarnitines (palmitoylcarnitine/octanoylcarnitine). d–f, Glucose uptake (d), blood flow (e) and arterial-venous glucose difference (f) in the prior rested and exercised leg during the 120 min insulin clamp. ‡Different from fasting in both groups. n = 5 in both groups (b–e) and n = 8 in Controls and n = 7 in TBC1D4 carriers (a). Data are means ± SEM. Data were analyzed using a two-way repeated ANOVA test (one factor repeated (a) and two factor repeated (b–e)) and two-tailed Student-Newman-Keuls post hoc analyses for multiple comparisons (a–e). LLM, leg lean mass.

Back to article page