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Cellular metabolism

Guardians of the cell: mitochondria as a rheostat for cellular NAD+ levels

Nature Metabolism volume 6, pages 2215–2217 (2024)Cite this article

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A new study reveals that subcellular NAD+ pools are interconnected, with mitochondria acting as a buffer to maintain NAD+-dependent processes in overconsuming organelles, highlighting the critical role of mitochondria in NAD+ homeostasis.

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Fig. 1: Interconnectivity of intracellular NAD+ pools and buffering function of mitochondria.

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Authors and Affiliations

  1. Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Fiona M. Fitzpatrick & Nora Kory

  2. Dana-Farber Cancer Institute, Boston, MA, USA

    Nora Kory

Authors
  1. Fiona M. Fitzpatrick
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  2. Nora Kory
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Correspondence to Nora Kory.

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The authors declare no competing interests.

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Fitzpatrick, F.M., Kory, N. Guardians of the cell: mitochondria as a rheostat for cellular NAD+ levels. Nat Metab 6, 2215–2217 (2024). https://doi.org/10.1038/s42255-024-01160-2

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