Extended Data Fig. 3: NAMPT restricts HSV-1 replication in mice.
From: Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins
a, Lysates of indicated tissues of wildtype and NAMPT-KO mice were analyzed by immunoblotting with indicated antibodies. b, Body weight of wildtype and NAMPT-KO mice was determined immediately before HSV-1 infection, n = 11. c, Hematolysin & Eosin (H&E) staining and UL37 immunohistochemistry staining of the liver of HSV-1-infected Namptfl/fl and Nampt−/− mice, with boxed region shown below. Scale bars, 50 μm. d, Body weight of wildtype (n = 13), NAMPT-KO (n = 10) and NAMPT-KO mice with nicotinamide riboside (NR) supplementation via intraperitoneal injection (n = 10) was determined immediately before HSV-1 infection. Statistical significance was calculated using unpaired two-tailed t-tests for b and d. Data are presented as mean values\(\pm\)SD.
